As a guitar player, Depp has played slide guitar on the Oasis song “Fade In-Out” (from Be Here Now, 1997), as well as on “Fade Away (Warchild Version)” (b-side of the “Don’t Go Away” single). He also played acoustic guitar in the movie Chocolat and on the soundtrack to Once Upon a Time in Mexico. He is a friend of The Pogues’ Shane MacGowan, and performed on MacGowan’s first solo album. He was also a member of P, a group featuring Butthole Surfers singer Gibby Haynes, Red Hot Chili Peppers bassist Flea and Sex Pistols guitarist Steve Jones. He has appeared in Tom Petty & The Heartbreakers’ music video “Into the Great Wide Open” and The Lemonheads “It’s a Shame About Ray” music video. He made a cameo as the Mad Hatter in the music video for Avril Lavigne’s “Alice” in 2010. He performed lead guitar and drums for a cover of Carly Simon’s “You’re So Vain”, which appeared as a bonus track on some editions of Marilyn Manson’s 2012 album Born Villain, also performing live with Marilyn Manson in the Revolver Golden Gods Awards 2012, performing various songs of Marilyn Manson. He also appeared in the music video of “My Valentine” from the album Kisses on the Bottom by Paul McCartney released in February 2012, along with Natalie Portman.
Depp traded licks with Joe Perry on “The Brooklyn Shuffle,” a song from Steve Hunter and “The Manhattan Blues Project,” which was scheduled for release on April 30, 2013.
Depp and Paradis grew grapes and had wine making facilities in their vineyard in Plan-de-la-Tour north of Saint-Tropez. Along with Sean Penn, John Malkovich and Mick Hucknall, Depp co-owned the French restaurant-bar Man Ray, located near the Champs-Élysées.
In July 2012, Depp announced he would be co-editor, alongside Douglas Brinkley, of folk singer Woody Guthrie’s unpublished novel House of Earth. The book was published in 2013.